Diaminopyrimidine
Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.
They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim[1] and the antibiotics iclaprim and trimethoprim).
Some have been patented as anti-cancer drugs.[2]
See also
[edit]References
[edit]- ^ http://aac.asm.org/cgi/content/full/45/12/3293 Archived 2008-08-29 at the Wayback Machine "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
- ^ "WO1998030550 - 2,4-DIAMINOPYRIMIDINE COMPOUNDS AS ANTI-CANCER AGENTS". Patentscope. WIPO. Retrieved 2025-06-03.
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