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2,4-Diaminopyrimidine

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2,4-Diaminopyrimidine[1]
Names
Preferred IUPAC name
Pyrimidine-2,4-diamine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.005.331 Edit this at Wikidata
EC Number
  • 205-862-3
UNII
  • InChI=1S/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8) checkY
    Key: YAAWASYJIRZXSZ-UHFFFAOYSA-N checkY
  • InChI=1/C4H6N4/c5-3-1-2-7-4(6)8-3/h1-2H,(H4,5,6,7,8)
    Key: YAAWASYJIRZXSZ-UHFFFAOYAE
  • C1=CN=C(N=C1N)N
  • n1c(N)ccnc1N
Properties
C4H6N4
Molar mass 110.12 g/mol
Melting point 143 to 147 °C (289 to 297 °F; 416 to 420 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

2,4-Diaminopyrimidine is an organic compound with the formula C4H2(NH2)2. It is the parent of one isomer of the diaminopyrimidines. Such compounds are structurally related to folic acid and the basis of much medicinal chemistry including the drug pyrimethamine.[2]

Further reading

[edit]
  • Irvine, Mark William (2020). "Agents acting on pyrimidine metabolism". Antimalarial Agents. pp. 133–185. doi:10.1016/b978-0-08-101210-9.00005-6. ISBN 978-0-08-101210-9.

See also

[edit]

References

[edit]
  1. ^ 2,4-Diaminopyrimidine at Sigma-Aldrich
  2. ^ Roth, Barbara; Cheng, C.C. (1982). 6 Recent Progress in the Medicinal Chemistry of 2,4-Diaminopyrimidines. Progress in Medicinal Chemistry. Vol. 19. pp. 269–331. doi:10.1016/s0079-6468(08)70332-1. ISBN 978-0-444-80415-0. PMID 6129679.
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