Template:2022 MLS Next Pro Central Division table
| Pos | Team | Pld | W | SOW | SOL | L | GF | GA | GD | Pts | Qualification |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Columbus Crew 2 | 24 | 16 | 2 | 3 | 3 | 62 | 22 | +40 | 55 | Qualification for the 2022 MLS Next Pro Playoffs |
| 2 | Inter Miami CF II | 24 | 10 | 1 | 4 | 9 | 40 | 49 | −9 | 36 | |
| 3 | Chicago Fire FC II | 24 | 8 | 2 | 3 | 11 | 41 | 44 | −3 | 31 | |
| 4 | Orlando City B | 24 | 6 | 2 | 3 | 13 | 40 | 53 | −13 | 25 | |
| 5 | FC Cincinnati 2 | 24 | 4 | 2 | 1 | 17 | 27 | 65 | −38 | 17 |
Source: MLSNP Central Division
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)