Taurodeoxycholic acid

Taurodeoxycholic acid
Names
	IUPAC name 2-(3α,12α-Dihydroxy-5β-cholan-24-amido)ethane-1-sulfonic acid
	Systematic IUPAC name 2-{(2R)-4-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-Dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanamido}ethane-1-sulfonic acid
Identifiers
CAS Number	516-50-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:9410 ;
ChEMBL	ChEMBL412272 ;
ChemSpider	2015539 ;
PubChem CID	2733768;
UNII	20668G0RPI ;
CompTox Dashboard (EPA)	DTXSID00873418 ;
	InChI InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1 Key: AWDRATDZQPNJFN-VAYUFCLWSA-N ; InChI=1/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1 Key: AWDRATDZQPNJFN-VAYUFCLWBR;
	SMILES C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C;
Properties
Chemical formula	C26H45NO6S
Molar mass	499.71 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Taurodeoxycholic acid is a bile acid. This compound is a closely related isomer of taurochenodeoxycholic acid and tauroursodeoxycholic acid sharing the exact molecular formula and molecular weight.

Taurodeoxycholic acid and its isomers have molecular masses similar to perfluorooctanesulfonic acid (PFOS) and therefore may interfere with interpretation of mass spectrometry data, leading to a false indication of the presence of PFOS in a biological sample.^[1]

Serum concentration of taurodeoxycholic acid, a downstream microbial metabolite of cholic acid, is associated with a strong increased risk of colorectal cancer among women.^[2]

Also, the determination of taurodeoxycholic acid 3-sulfate in blood samples may potentially be useful as a risk factor and screening biomarker for lung cancer prevention.^[3]

References

^ Benskin, Jonathan P.; Bataineh, Mahmoud; Martin, Jonathan W. (2007). "Simultaneous Characterization of Perfluoroalkyl Carboxylate, Sulfonate, and Sulfonamide Isomers by Liquid Chromatography−Tandem Mass Spectrometry". Analytical Chemistry. 79 (17): 6455–64. doi:10.1021/ac070802d. PMID 17665875.
^ Loftfield E, Falk RT, Sampson JN, Huang WY, Hullings A, Murphy G, Weinstein SJ, Albanes D, Freedman ND, Sinha R (May 2022). "Prospective Associations of Circulating Bile Acids and Short-Chain Fatty Acids With Incident Colorectal Cancer". JNCI Cancer Spectr. 6 (3): pkac027. doi:10.1093/jncics/pkac027. PMC 9115675. PMID 35583137.
^ Tang Z, Liang D, Deubler EL, Sarnat JA, Chow SS, Diver WR, Wang Y (June 2024). "Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies". BMC Med. 22 (1): 262. doi:10.1186/s12916-024-03473-1. PMC 11197282. PMID 38915026.

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[1] Benskin, Jonathan P.; Bataineh, Mahmoud; Martin, Jonathan W. (2007). "Simultaneous Characterization of Perfluoroalkyl Carboxylate, Sulfonate, and Sulfonamide Isomers by Liquid Chromatography−Tandem Mass Spectrometry". Analytical Chemistry. 79 (17): 6455–64. doi:10.1021/ac070802d. PMID 17665875.

[2] Loftfield E, Falk RT, Sampson JN, Huang WY, Hullings A, Murphy G, Weinstein SJ, Albanes D, Freedman ND, Sinha R (May 2022). "Prospective Associations of Circulating Bile Acids and Short-Chain Fatty Acids With Incident Colorectal Cancer". JNCI Cancer Spectr. 6 (3): pkac027. doi:10.1093/jncics/pkac027. PMC 9115675. PMID 35583137.

[3] Tang Z, Liang D, Deubler EL, Sarnat JA, Chow SS, Diver WR, Wang Y (June 2024). "Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies". BMC Med. 22 (1): 262. doi:10.1186/s12916-024-03473-1. PMC 11197282. PMID 38915026.

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