Talk:Alberto Izzotti

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HRShami (talk · contribs) has been paid by Alberto Izzotti.

de-orphaned

This edit request by an editor with a conflict of interest has now been answered.

Hi. Please remove the orphan tag from this article. I have created a link from this article. HRShami (talk) 11:04, 14 July 2025 (UTC)[reply]

Done Encoded Talk 💬 07:48, 16 July 2025 (UTC)[reply]

Research section

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Based on the tags on the page, I have changed some references and provided details here of where each statement is taken from. Please note his name is misspelled in some references as Izzoti or Izotti.

Please replace the current research section with the text below. The details of the exact sentences in the reference will need to be removed before placing the text on the page. If a volunteer reviews this and allows me, I can update the research section.

In his research related to chemoprevention and cancer, Izzotti studied the effectiveness of chemopreventive drugs in preventing cancer and other mutation-related diseases. He reviewed the mechanisms by which chemopreventive drugs offer a promising treatment for most cancers, with particular emphasis on smoking-related end-points. The results of his study established that chemopreventive drugs are effective in preclinical models for modulating a variety of DNA damage as well as cancer-related end-points. [page 26, paragraph 2] ^[1] He also investigated microRNA (miRNA) responses to noxious agents in healthy tissues, as well as the expression of 484 miRNA responses in lungs, demonstrating that miRNA impairment in lungs is induced by exposure to cigarette smoke. [page 2, paragraph 2] ^[2] It was also found that miRNA alterations occur as an early response in the tissue of cells exposed to environmental carcinogens before the onset of cancer. [page 24, introduction, paragraph 3] ^[3] In related research, he also deduced the presence of extra-cellular miRNAs in biological fluids in order to determine their feasibility as potential cancer markers that can be detected through non-invasive procedures. [page 4, paragraph 4 and paragraph 6] ^[4] It was then found that some panels of miRNAs can emerge as cancer biomarkers, [please search reference 42] but there is a need to identify more specific and reliable miRNA panels to be used as cancer biomarkers. [page 5, second last paragraph] ^[5]

Izzotti also investigated the causes of the molecular mechanisms responsible for the development of glaucoma, a leading cause of irreversible blindness. He assessed DNA damage in the trabecular meshwork of eyes of glaucoma patients and found that levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) were significantly higher in glaucoma patients. [please search reference 103] ^[6]

In similar research, he examined the levels of 8-OH-dG in relation to intraocular pressure, visual field damage, and disease duration. [Line 8, page 235] The results of this study found the presence of oxidative damage alongside neuronal cell death in optic nerves among patients with primary open-angle glaucoma (POAG), [line 42, page 235] which supported the possible pathogenetic role of this phenomenon. [Line 30, page 235] Correspondingly, he also analyzed the role of mitochondrial damage in the eye of POAG patients and found that mitochondrial DNA deletion was significantly increased in the human trabecular meshwork within POAG patients. [Line 40, page 235]^[7] HRShami (talk)

^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
^ Russ, Rebecca; Slack, Frank J. (2012). "Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis". Pulmonary Medicine. 2012: 1–9. doi:10.1155/2012/791234.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
^ Donzelli, Sara; Farneti, Alessia; Marucci, Laura; Ganci, Federica; Sacconi, Andrea; Strano, Sabrina; Sanguineti, Giuseppe; Blandino, Giovanni (21 April 2020). "Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia". Frontiers in Cell and Developmental Biology. 8: 257. doi:10.3389/fcell.2020.00257. PMC 7187787. PMID 32373612.
^ Robotti, Marzia; Scebba, Francesca; Angeloni, Debora (21 February 2023). "Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?". Biomedicines. 11 (3): 652. doi:10.3390/biomedicines11030652.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Passaro, Maria Laura; Matarazzo, Francesco; Abbadessa, Gianmarco; Pezone, Antonio; Porcellini, Antonio; Tranfa, Fausto; Rinaldi, Michele; Costagliola, Ciro (2 November 2023). "Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?". Journal of Clinical Medicine. 12 (21): 6900. doi:10.3390/jcm12216900.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Majsterek, Ireneusz; Malinowska, Katarzyna; Stanczyk, Malgorzata; Kowalski, Michal; Blaszczyk, Jan; Kurowska, Anna K.; Kaminska, Anna; Szaflik, Jerzy; Szaflik, Jacek P. (April 2011). "Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma". Experimental and Molecular Pathology. 90 (2): 231–237. doi:10.1016/j.yexmp.2011.01.001. PMID 21241689.

[1] Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.

[2] Russ, Rebecca; Slack, Frank J. (2012). "Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis". Pulmonary Medicine. 2012: 1–9. doi:10.1155/2012/791234.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[3] Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.

[4] Donzelli, Sara; Farneti, Alessia; Marucci, Laura; Ganci, Federica; Sacconi, Andrea; Strano, Sabrina; Sanguineti, Giuseppe; Blandino, Giovanni (21 April 2020). "Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia". Frontiers in Cell and Developmental Biology. 8: 257. doi:10.3389/fcell.2020.00257. PMC 7187787. PMID 32373612.

[5] Robotti, Marzia; Scebba, Francesca; Angeloni, Debora (21 February 2023). "Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?". Biomedicines. 11 (3): 652. doi:10.3390/biomedicines11030652.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[6] Passaro, Maria Laura; Matarazzo, Francesco; Abbadessa, Gianmarco; Pezone, Antonio; Porcellini, Antonio; Tranfa, Fausto; Rinaldi, Michele; Costagliola, Ciro (2 November 2023). "Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?". Journal of Clinical Medicine. 12 (21): 6900. doi:10.3390/jcm12216900.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[7] Majsterek, Ireneusz; Malinowska, Katarzyna; Stanczyk, Malgorzata; Kowalski, Michal; Blaszczyk, Jan; Kurowska, Anna K.; Kaminska, Anna; Szaflik, Jerzy; Szaflik, Jacek P. (April 2011). "Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma". Experimental and Molecular Pathology. 90 (2): 231–237. doi:10.1016/j.yexmp.2011.01.001. PMID 21241689.

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