Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
| phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The enzyme as folded by AlphaFold | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.4.57 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase, known also as Cyclic phosphate dihydrolase is a hydrolase enzyme found in various species of bacteria. The enzyme uses water to catalyze the hydrolysis of a cyclic ribophosphate to form alpha-D-ribose 1,5-bisphosphate.[1] Formally, the enzyme catalyzes the following chemical reactions,
- alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H+
- D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate + H+
In Eggerthella lenta, Gordonibacter urolithinfaciens and Gordonibacter pamelaeae, the enzyme is encoded by the gene phnPP. The protein consists of 252 amino acids. The enzyme is known to have metal-ion binding sites for Mn2+ and Zn2+. The enzyme is involved in the catabolism of organophosphonates.[2][3]
References
[edit]- ^ "ENZYME entry: EC 3.1.4.57". ExPasy. Database. 2025. Retrieved 6 May 2025.
- ^ "EC Explorer". Brenda. 2025. Retrieved 6 May 2025.
- ^ "5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase". MetaCyc. Retrieved 6 May 2025.
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