PSKH1

PSKH1
Identifiers
Aliases	PSKH1, protein serine kinase H1
External IDs	OMIM: 177015; MGI: 3528383; HomoloGene: 48461; GeneCards: PSKH1; OMA:PSKH1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,929,676 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,658,410 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; mucosa of transverse colon; ; apex of heart; ; body of stomach; ; body of pancreas; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; left ovary; ; left adrenal cortex;
	Top expressed in
	hand; ; genital tubercle; ; zygote; ; internal carotid artery; ; tail of embryo; ; external carotid artery; ; secondary oocyte; ; foot; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; Golgi apparatus; nuclear speck; endoplasmic reticulum membrane; membrane; plasma membrane; microtubule organizing center; endoplasmic reticulum; cytoskeleton; nucleus; intracellular anatomical structure; nucleoplasm; cellular component;
Biological process	phosphorylation; protein phosphorylation; heart development; determination of left/right symmetry; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5681
	244631
	ENSG00000159792
	ENSMUSG00000048310
	P11801
	Q91YA2
	NM_006742
	NM_173432
	NP_006733
	NP_775608
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Serine/threonine-protein kinase H1 is a Ser/Thr protein kinase that is encoded by the PSKH1 gene in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the Endoplasmic Reticulum.^[5]^[6]

Interactions

PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to interact with (and be regulated by) proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and calmodulin. It is also activated by UNC119B, an acyl chain binding protein.^[7] PSKH1 is closely related to the catalytically-inactive pseudokinase PSKH2, which is also membrane-localised within the secretory pathway.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159792 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
^ "Entrez Gene: PSKH1 protein serine kinase H1".
^ Horne CR, Young SY, Mather LJ, Dagley LF, Johnson JL, Yaron-Barir TM, Huntsman EM, Daly LA, Byrne DP, Cadell AL, Ng BH, Yousef J, Multari DH, Shen L, McAloon LM, Manning G, Febbraio MA, Means AR, Cantley LC, Tanzer MC, Croucher DR, Eyers CE, Eyers PA, Scott JW, and Murphy JM (February 2025). "PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins". PNAS. 122 (8). doi:10.1073/pnas.2420961122. PMC 11873932. PMID 39964718.
^ Byrne DP, Shrestha S, Daly LA, Marensi V, Ramakrishnan K, Eyers CE, Kannan N, and Eyers PA (January 2023). "Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2". Biochemical Journal. 480 (2): 141–160. doi:10.1042/BCJ20220474. PMC 11873932. PMID 39964718.

Hanks SK (1987). "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. Bibcode:1987PNAS...84..388H. doi:10.1073/pnas.84.2.388. PMC 304212. PMID 2948189.
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.
Amarzguioui M, Brede G, Babaie E, Grotli M, Sproat B, Prydz H (2000). "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes". Nucleic Acids Res. 28 (21): 4113–24. doi:10.1093/nar/28.21.4113. PMC 113158. PMID 11058107.
Brede G, Solheim J, Tröen G, Prydz H (2001). "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization". Genomics. 70 (1): 82–92. doi:10.1006/geno.2000.6365. PMID 11087665.
Brede G, Solheim J, Prydz H (2002). "PSKH1, a novel splice factor compartment-associated serine kinase". Nucleic Acids Res. 30 (23): 5301–9. doi:10.1093/nar/gkf648. PMC 137962. PMID 12466556.
Brede G, Solheim J, Stang E, Prydz H (2004). "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus". Exp. Cell Res. 291 (2): 299–312. doi:10.1016/j.yexcr.2003.07.009. PMID 14644153.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159792 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8268911-5] Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.

[entrez-6] "Entrez Gene: PSKH1 protein serine kinase H1".

[pmid39964718-7] Horne CR, Young SY, Mather LJ, Dagley LF, Johnson JL, Yaron-Barir TM, Huntsman EM, Daly LA, Byrne DP, Cadell AL, Ng BH, Yousef J, Multari DH, Shen L, McAloon LM, Manning G, Febbraio MA, Means AR, Cantley LC, Tanzer MC, Croucher DR, Eyers CE, Eyers PA, Scott JW, and Murphy JM (February 2025). "PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins". PNAS. 122 (8). doi:10.1073/pnas.2420961122. PMC 11873932. PMID 39964718.

[pmid36520605-8] Byrne DP, Shrestha S, Daly LA, Marensi V, Ramakrishnan K, Eyers CE, Kannan N, and Eyers PA (January 2023). "Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2". Biochemical Journal. 480 (2): 141–160. doi:10.1042/BCJ20220474. PMC 11873932. PMID 39964718.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading