PIPE-359

PIPE-359
Identifiers
	IUPAC name 6-[3-[3-(1,3-benzothiazol-7-ylsulfonyl)propanoyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridine-3-carbonitrile;
CAS Number	2401785-66-6;
PubChem CID	152278786;
ChemSpider	129483116;
ChEMBL	ChEMBL4790083;
Chemical and physical data
Formula	C22H21N5O3S2
Molar mass	467.56 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC2CN(CC1N2C3=NC=C(C=C3)C#N)C(=O)CCS(=O)(=O)C4=CC=CC5=C4SC=N5;
	InChI InChI=1S/C22H21N5O3S2/c23-10-15-4-7-20(24-11-15)27-16-5-6-17(27)13-26(12-16)21(28)8-9-32(29,30)19-3-1-2-18-22(19)31-14-25-18/h1-4,7,11,14,16-17H,5-6,8-9,12-13H2; Key:WKWYANDGYZVVAK-UHFFFAOYSA-N;

PIPE-359 is an experimental drug that acts as a potent and selective antagonist of the muscarinic acetylcholine receptor M1. It has been investigated for potential application in remyelination of nerve sheaths for the treatment of multiple sclerosis.^[1]

References

^ Schrader TO, Xiong Y, Lorenzana AO, Broadhead A, Stebbins KJ, Poon MM, et al. (January 2021). "Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE". ACS Medicinal Chemistry Letters. 12 (1): 155–161. doi:10.1021/acsmedchemlett.0c00626. PMC 7812680. PMID 33488977.

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[Schrader_2021-1] Schrader TO, Xiong Y, Lorenzana AO, Broadhead A, Stebbins KJ, Poon MM, et al. (January 2021). "Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAE". ACS Medicinal Chemistry Letters. 12 (1): 155–161. doi:10.1021/acsmedchemlett.0c00626. PMC 7812680. PMID 33488977.

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