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Mikala Egeblad

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Mikala Egeblad
Alma materUniversity of Copenhagen
Scientific career
ThesisErbB receptors and ligands in breast cancer (1999)
Doctoral advisorZena Werb

Mikala Egeblad is a Bloomburg Distinguished Professor at Johns Hopkins School of Medicine. She is known for her research into cancer, and how it spreads in humans.

Education and career

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Egeblad attended the University of Copenhagen where she earned a bachelor’s degree in medicine, a master’s degree in human biology and a Ph.D. in cancer biology. Following her PhD, she trained as a postdoctoral fellow at University of California, San Francisco[1] where she worked with Zena Werb.[2] In 2009, she established her own lab at Cold Spring Harbor Laboratory where she worked until moving to Johns Hopkins School of Medicine as a Bloomberg Distinguished Professor in 2023.[1]

Research

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Egeblad's research is centered on understanding how the body’s immune response influences cancer progression, metastasis, and therapy outcomes. While at the University of California, San Francisco, Egeblad used mouse models to research the cancerous tumor microenvironment, focusing on the contribution of the innate immune system and matrix metalloproteinases.[3] Egeblad also co-developed a technique of intravital imaging, using a 2-photon microscope and silicone window implant to capture immune cell behavior in real time.[4][5]

After she moved to Cold Spring Harbor she continued to study the tumor microenvironment, foscusing on the interactions between cancer cells and their surrounding stromal cells.[6] Her work has helped define the mechanisms by which neutrophils induce the progression of cancer and its metastasis.[7]

Honors and awards

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In 2017 Egeblad received the Pershing Square Sohn Prize from the Sohn Conference Foundation.[8] She received the Suffrage Science award from her mentor Marja Jäättelä [fi] in 2018.[9][10]

Selected publications

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  • Egeblad, Mikala; Werb, Zena (2002). "New functions for the matrix metalloproteinases in cancer progression". Nature Reviews Cancer. 2 (3): 161–174. doi:10.1038/nrc745. ISSN 1474-175X. Retrieved 2025-06-15.
  • Egeblad, Mikala; Nakasone, Elizabeth S.; Werb, Zena (2010). "Tumors as Organs: Complex Tissues that Interface with the Entire Organism". Developmental Cell. 18 (6): 884–901. doi:10.1016/j.devcel.2010.05.012. PMC 2905377. PMID 20627072. Retrieved 2025-06-15.
  • Albrengues, Jean; Shields, Mario A.; Ng, David; Park, Chun Gwon; Ambrico, Alexandra; Poindexter, Morgan E.; Upadhyay, Priya; Uyeminami, Dale L.; Pommier, Arnaud; Küttner, Victoria; Bružas, Emilis; Maiorino, Laura; Bautista, Carmelita; Carmona, Ellese M.; Gimotty, Phyllis A.; Fearon, Douglas T.; Chang, Kenneth; Lyons, Scott K.; Pinkerton, Kent E.; Trotman, Lloyd C.; Goldberg, Michael S.; Yeh, Johannes T.-H.; Egeblad, Mikala (2018-09-28). "Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice". Science. 361 (6409). doi:10.1126/science.aao4227. ISSN 0036-8075. PMC 6777850. PMID 30262472.
  • Barnes, Betsy J.; Adrover, Jose M.; Baxter-Stoltzfus, Amelia; Borczuk, Alain; Cools-Lartigue, Jonathan; Crawford, James M.; Daßler-Plenker, Juliane; Guerci, Philippe; Huynh, Caroline; Knight, Jason S.; Loda, Massimo; Looney, Mark R.; McAllister, Florencia; Rayes, Roni; Renaud, Stephane; Rousseau, Simon; Salvatore, Steven; Schwartz, Robert E.; Spicer, Jonathan D.; Yost, Christian C.; Weber, Andrew; Zuo, Yu; Egeblad, Mikala (2020-06-01). "Targeting potential drivers of COVID-19: Neutrophil extracellular traps" (PDF). Journal of Experimental Medicine. 217 (6). doi:10.1084/jem.20200652. ISSN 0022-1007. PMC 7161085. PMID 32302401. Retrieved 2025-06-15.

References

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  1. ^ a b Weder, Annika (2023-06-27). "Mikala Egeblad wants to put the brakes on cancer progression". Johns Hopkins University. Retrieved 2025-06-15.
  2. ^ Egeblad, Mikala; Coussens, Lisa M.; Weaver, Valerie M. (2020-08-03). "Zena Werb 1945–2020". Nature Cancer. 1 (8): 753–754. doi:10.1038/s43018-020-0101-z. ISSN 2662-1347.
  3. ^ Egeblad, Mikala; Werb, Zena (2002). "New functions for the matrix metalloproteinases in cancer progression". Nature Reviews Cancer. 2 (3): 161–174. doi:10.1038/nrc745. ISSN 1474-175X.
  4. ^ Ewald, Andrew J.; Werb, Zena; Egeblad, Mikala (2011). "Preparation of Mice for Long-Term Intravital Imaging of the Mammary Gland: FIGURE 1". Cold Spring Harbor Protocols. 2011 (2): pdb.prot5562. doi:10.1101/pdb.prot5562. ISSN 1940-3402. PMC 3531961. PMID 21285262.
  5. ^ Egeblad, Mikala; Ewald, Andrew J.; Askautrud, Hanne A.; Truitt, Morgan L.; Welm, Bryan E.; Bainbridge, Emma; Peeters, George; Krummel, Matthew F.; Werb, Zena (2008-09-26). "Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy". Disease Models & Mechanisms. 1 (2–3): 155–167. doi:10.1242/dmm.000596. ISSN 1754-8403. PMC 2562195. PMID 19048079.
  6. ^ Nakasone, Elizabeth S.; Askautrud, Hanne A.; Kees, Tim; Park, Jae-Hyun; Plaks, Vicki; Ewald, Andrew J.; Fein, Miriam; Rasch, Morten G.; Tan, Ying-Xim; Qiu, Jing; Park, Juwon; Sinha, Pranay; Bissell, Mina J.; Frengen, Eirik; Werb, Zena (2012-04-17). "Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance". Cancer Cell. 21 (4): 488–503. doi:10.1016/j.ccr.2012.02.017. ISSN 1535-6108. PMC 3332002. PMID 22516258.
  7. ^ Park, Juwon; Wysocki, Robert W.; Amoozgar, Zohreh; Maiorino, Laura; Fein, Miriam R.; Jorns, Julie; Schott, Anne F.; Kinugasa-Katayama, Yumi; Lee, Youngseok; Won, Nam Hee; Nakasone, Elizabeth S.; Hearn, Stephen A.; Küttner, Victoria; Qiu, Jing; Almeida, Ana S. (2016-10-19). "Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps". Science Translational Medicine. 8 (361). doi:10.1126/scitranslmed.aag1711. ISSN 1946-6234. PMC 5550900. PMID 27798263.
  8. ^ "Mikala Egeblad". Pershing Square Philanthropies. Retrieved 2025-06-15.
  9. ^ "Life Sciences 2018: Nomination and Acceptance Speeches". Suffrage Science. 2018-06-06. Retrieved 2025-06-15.
  10. ^ Alfano, Andrea (2018-06-08). "Suffrage Science award to Mikala Egeblad". Cold Spring Harbor Laboratory. Retrieved 2025-06-15.
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