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Magnesium asparaginate

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Magnesium asparaginate
Clinical data
ATC code
Identifiers
  • magnesium;(2S)-2,4-diamino-4-oxobutanoate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H14MgN4O6
Molar mass286.527 g·mol−1
3D model (JSmol)
  • C([C@@H](C(=O)[O-])N)C(=O)N.C([C@@H](C(=O)[O-])N)C(=O)N.[Mg+2]
  • InChI=InChI=1S/2C4H8N2O3.Mg/c2*5-2(4(8)9)1-3(6)7;/h2*2H,1,5H2,(H2,6,7)(H,8,9);/q;;+2/p-2/t2*2-;/m00./s1
  • Key:ZHYLJCKTXNWNPJ-CEOVSRFSSA-L

Magnesium asparaginate is a magnesium salt of asparagine, an amino acid.[1]

Magnesium asparaginate has been referenced in limited contexts, primarily as a component in a potassium and magnesium asparaginate solution used in cardiac surgery to maintain electrolyte balance.[2]

It is not approved as a standalone therapeutic agent or dietary supplement in major jurisdictions such as the United States or European Union.

Medical uses

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Magnesium asparaginate similar to other magnesium amino acid chelates could potentially be used as a mineral supplement to prevent and treat magnesium deficiency (hypomagnesemia), which can arise from conditions such as poor diet, alcoholism, certain medications like diuretics, or gastrointestinal disorders that impair absorption.[3] Magnesium is vital for normal cellular, nerve, muscle, bone, and heart function. Magnesium asparaginate has good oral bioavailability.[3] It is also investigated for its potential benefits in chronic fatigue and recovery after cardiac surgery.[4][5]

Research

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Magnesium asparaginate's documented use is limited to a single clinical study in cardiac surgery, where it was combined with potassium aspartate in an intravenous solution to maintain electrolyte balance during coronary artery procedures.[6][5]

This application is investigational, and Magnesium asparaginate is not standard in cardiac care protocols.[7][6]

Comparison with magnesium aspartate

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While both magnesium asparaginate and magnesium aspartate are magnesium salts of amino acids, the key difference lies in the amino acids used. Magnesium asparaginate is derived from asparagine, whereas magnesium aspartate is derived from aspartic acid. Both forms serve as magnesium supplements with similar absorption characteristics, magnesium asparaginate is typically used in clinical settings for electrolyte management,[4][5] whereas magnesium aspartate is more common in oral supplementation for conditions related to magnesium deficiency.[8]

Chemistry

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Magnesium asparaginate, also known as magnesium L-asparaginate, is the magnesium salt of the amino acid asparagine.[2] Its molecular formula is C
8H
14MgN
4O
6, indicating that two molecules of asparagine coordinate with one magnesium ion to form a neutral compound.[1] In this structure, the divalent magnesium ion (Mg²⁺) is chelated by the asparaginate anions, which contain both amino and carboxyl groups, allowing for stable binding. This chelation enhances the water solubility of the compound, which is important for its absorption and bioavailability as a dietary supplement. Magnesium asparaginate is used to provide magnesium, an essential mineral involved in numerous physiological processes, and asparagine, which plays a role in protein synthesis and cellular metabolism.[1] The coordination chemistry of magnesium asparaginate is similar to other amino acid-magnesium complexes, where the amino acid ligands stabilize the magnesium ion in solution, contributing to its favorable pharmacokinetic properties.[9][6]

See also

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References

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  1. ^ a b c "Magnesium asparaginate". PubChem. U.S. National Library of Medicine. 2016-11-20. Retrieved 2025-05-20.
  2. ^ a b Aksel'Rod BA, Tolstova IA, Andrianova MI, Trekova NA (2011-06-01). "Use of a potassium and magnesium asparaginate solution". Anesteziologiia I Reanimatologiia (3): 8–13. PMID 21853612. Retrieved 2025-05-20.
  3. ^ a b Szyszka A, Kaźmierczak E, Dziegielewska G, Lowicki Z, Mrozikewicz A (July 1994). "[Assessment of bioavailability of magnesium preparations]". Wiadomosci Lekarskie (in Polish). 47 (13–14). Warsaw, Poland: 481–3. PMID 7716929.
  4. ^ a b Görög P, Ezer E, Szporny L (November 1966). "Effect of magnesium asparaginate on the coronary circulation". Arzneimittel-Forschung. 16 (11): 1488–90. PMID 6014963.
  5. ^ a b c Trekova NA, Andrianova MI, Tolstova IA, Aksel'rod BA, Zaĭtseva SV, Morozov I (2008). "[Use of a potassium and magnesium asparaginate solution to maintain the balance of potassium and magnesium during cardiosurgical interventions under extracorporeal circulation]". Anesteziologiia I Reanimatologiia (in Russian) (5): 17–21. PMID 19105253.
  6. ^ a b c Soliman R, Abukhudair W (2019). "The perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing cardiac surgery: A double-blinded randomized study". Annals of Cardiac Anaesthesia. 22 (3): 246–253. doi:10.4103/aca.ACA_34_18. ISSN 0971-9784. PMC 6639894. PMID 31274484.
  7. ^ Aksel'rod BA, Tolstova IA, Andrianova MI, Trekova NA (2011). "[The role of magnesium in the implementation of vascular reactions during anesthesia in cardiac surgery patients]". Anesteziologiia I Reanimatologiia (3): 8–13. ISSN 0201-7563. PMID 21853612.
  8. ^ "Magnesium Aspartate". Drugs.com.
  9. ^ Case DR, Zubieta J, P Doyle R (July 2020). "The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes". Molecules. 25 (14). Basel, Switzerland: 3172. doi:10.3390/molecules25143172. PMC 7397051. PMID 32664540.
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