MYO18B

MYO18B
Identifiers
Aliases	MYO18B, KFS4, myosin XVIIIB
External IDs	OMIM: 607295; MGI: 1921626; HomoloGene: 53435; GeneCards: MYO18B; OMA:MYO18B - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	26,031,045 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,044,228 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; left ventricle; ; Skeletal muscle tissue of biceps brachii; ; right auricle of heart; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; right ventricle;
	Top expressed in
	muscle of thigh; ; esophagus; ; spermatid; ; lip; ; skeletal muscle tissue; ; lens; ; embryo; ; quadriceps femoris muscle; ; superior frontal gyrus; ; heart;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; actin binding; cytoskeletal motor activity; ATP binding; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; unconventional myosin complex; sarcomere; nucleus; myosin complex; Z discdkac; filamentous actin;
Biological process	microtubule-based movement; vasculogenesis; in utero embryonic development;
	Sources:Amigo / QuickGO
Orthologs
	84700
	74376
	ENSG00000133454
	ENSMUSG00000072720
	Q8IUG5
	n/a
	NM_032608; NM_001318245
	NM_028901
	NP_001305174; NP_115997
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.^[5]^[6]^[7]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133454 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072720 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. Bibcode:2002PNAS...9912269N. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.
^ Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.
^ ^a ^b "Entrez Gene: MYO18B myosin XVIIIB".

Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677. S2CID 22741542.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer. 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387. S2CID 25091930.
Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. doi:10.3727/000000006783981062. PMID 17294804.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133454 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072720 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12209013-5] Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. Bibcode:2002PNAS...9912269N. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.

[pmid12547197-6] Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.

[entrez-7] "Entrez Gene: MYO18B myosin XVIIIB".

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References

Further reading