MRS8209

MRS8209
Identifiers
	IUPAC name 4-[6-(cyclopentylamino)-2-iodopurin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carbonitrile;
Chemical and physical data
Formula	C17H19IN6O2
Molar mass	466.283 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@H]1[C@@H](O)[C@@H]([C@H]2C[C@]21C#N)n1cnc2c1nc(I)nc2NC1CCCC1;

MRS8209 is an experimental drug which acts as a potent, peripherally selective 5-HT_2B receptor antagonist with high selectivity over other serotonin receptor subtypes. It has been investigated for possible applications in the treatment of heart and lung fibrosis and intestinal or vascular conditions mediated by 5-HT_2B, while sparing 5-HT_2B mediated activity in the brain.^[1]

References

^ Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, et al. (December 2024). "Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity". Journal of Medicinal Chemistry. 67 (23): 21264–21291. doi:10.1021/acs.jmedchem.4c02174. PMID 39589936.

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[Tosh_2024-1] Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, et al. (December 2024). "Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity". Journal of Medicinal Chemistry. 67 (23): 21264–21291. doi:10.1021/acs.jmedchem.4c02174. PMID 39589936.

[1]

See also

References