Isotonitazepyne
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| Formula | C23H28N4O3 |
| Molar mass | 408.502 g·mol−1 |
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Isotonitazepyne (N-pyrrolidino isotonitazene) is a benzimidazole derivative with potent opioid effects, which has been sold as a designer drug over the internet. It was first identified by the drug checking service CanTEST in Australia in September 2024, [1][2] and then later in Netherlands in May 2025. [3] Its in vitro potency is approximately 1000 times that of morphine.[4]
Legal Status
[edit]This section is not exhaustive and does not include information for all countries with laws covering isotonitazepyne.
USA
[edit]Virginia
[edit]It is specifically listed as an illegal drug in the US state of Virginia.[5]
United Kingdom
[edit]Since 15 January 2025 it is covered by the UK's generic definition on 2-benzyl benzimidazole derived opioids[6][7] because it contains the backbone with only the following modifications:[8]
- The nitrogen of the ethanamine (and no other atoms of the side chain) is included in a cyclic structure.
- The phenyl ring of the benzyl system is substituted by an alkoxy group containing three carbon atoms.
- The 5- position of the benzimidazole system is substituted by a nitro group.
See also
[edit]References
[edit]- ^ "N-pyrrolidino isotonitazene found in counterfeit oxycodone pill r". CanTEST. 9 September 2024. Archived from the original on 9 September 2024. Retrieved 9 September 2024 – via Instagram.
- ^ Lawes DJ, Caldicott D, McLeod MD, Curtis B. "Identification of the Novel Synthetic Opioid N-Pyrrolidino Isotonitazene at an Australian Drug Checking Service". Drug Testing and Analysis. n/a (n/a). doi:10.1002/dta.3910. ISSN 1942-7611. PMID 40384477.
- ^ kevino (2025-03-18). "Waarschuwing: Namaak-oxycodonpillen met het levensgevaarlijke isotonitazepyne in omloop". Trimbos-instituut (in Dutch). Retrieved 2025-05-30.
- ^ De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, et al. (September 2024). "In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids". Archives of Toxicology. 98 (9): 2999–3018. doi:10.1007/s00204-024-03774-7. PMC 11324687. PMID 38877156.
- ^ "18VAC110-20-322. Placement of chemicals in Schedule I." Code of Virginia. 2023.
- ^ "The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2024 and The Misuse of Drugs and Misuse of Drugs (Designation) (England and Wales and Scotland) (Amendment) (No. 2) Regulations 2024". GOV.UK. Retrieved 2025-05-30.
- ^ "Britain working at pace to curb rising synthetic drugs threat". GOV.UK. Retrieved 2025-06-12.
- ^ "Nitazenes detected in fake oxycodone tablets in Europe and the UK – Reagent Tests UK". www.reagent-tests.uk. Retrieved 2025-06-20.
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