Draft:Yuichi Wakabayashi

Yuichi Wakabayashi
Yuichi Wakabayashi
Born	Japan
Nationality	Japanese
Alma mater	Kobe University School of Medicine (M.D., Ph.D.)
Known for	PET-probe development; Regenerative medicine
	Scientific career
Fields	Regenerative medicine; Diagnostic radiology; Nuclear medicine
Institutions	Kinki University School of Medicine; National Institutes of Health

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Yuichi Wakabayashi (Japanese: 若林雄一, Wakabayashi Yūichi) is a Japanese physician and medical researcher specializing in regenerative medicine and diagnostic radiology. He is the founder and current director of CELL GRAND CLINIC, a Regenerative Medicine Center located in Osaka, Japan.^[1]

Education and career

Wakabayashi graduated from Kobe University School of Medicine (M.D.) and earned his Ph.D. from Kobe University Graduate School of Medicine. He then served as a lecturer at Kinki University School of Medicine before joining the National Institutes of Health (NIH) in the United States as a visiting researcher, where he focused on molecular imaging. In March 2025, he established CELL GRAND CLINIC in Osaka, offering advanced regenerative therapies such as stem cell transplantation and exosome treatment.^[1]

Research

His work centers on the development of positron emission tomography (PET) probes targeting phosphodiesterase-4 (PDE4) isoforms. In 2022, his team reported the first-in-human evaluation of ¹⁸F-PF-06445974, the first PDE4B-selective radioligand, demonstrating its safety and imaging potential.^[2]

Selected publications

Wakabayashi, Yuichi (2022). “First-in-Human Evaluation of ¹⁸F-PF-06445974, a PDE4B-selective PET Radioligand.” Journal of Nuclear Medicine. 63 (12): 1919–1924. doi:10.2967/jnumed.122.263838.
Wakabayashi, Yuichi (2020). “Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for PET Imaging of Brain PDE4D.” ACS Chemical Neuroscience. 11: 1311–1323. doi:10.1021/acschemneuro.0c00077.
Wakabayashi, Yuichi (2018). “Semi-quantitative Dopamine Transporter SUV vs Conventional SBR in [123I]FP-CIT SPECT.” Neurological Sciences. 39: 1401–1407. doi:10.1007/s10072-018-3437-8.

Books

Wakabayashi, Yuichi (2025). The World’s Easiest Basic Knowledge of Regenerative Medicine (English Edition) [Kindle edition]. Amazon. Retrieved 11 June 2025.https://www.amazon.co.jp/dp/B0F7373MWW

Professional qualifications and memberships

Board-certified specialist, American Academy of Regenerative Medicine (AARM)
Board-certified diagnostic radiologist, Japan Radiological Society
Board-certified nuclear medicine specialist, Japanese Society of Nuclear Medicine
Member, Japanese Society for Regenerative Medicine
Member, Japan Society of Anti-Aging Medicine

External links

[Official website of CELL GRAND CLINIC](https://cellgrandclinic.com/) (Japanese)
[Yuichi Wakabayashi’s profile on Tokitsukaze Publishing](https://tokitsukaze.co.jp/voice/xxxxx)

References

^ ^a ^b "About – CELL GRAND CLINIC". CELL GRAND CLINIC (in Japanese). Retrieved 11 June 2025.
^ Wakabayashi, Yuichi (2022). "First-in-Human Evaluation of ¹⁸F-PF-06445974, a PDE4B-selective PET Radioligand". Journal of Nuclear Medicine. 63 (12): 1919–1924. doi:10.2967/jnumed.122.263838.

[CGC-about2-1] "About – CELL GRAND CLINIC". CELL GRAND CLINIC (in Japanese). Retrieved 11 June 2025.

[JNM2022-2] Wakabayashi, Yuichi (2022). "First-in-Human Evaluation of ¹⁸F-PF-06445974, a PDE4B-selective PET Radioligand". Journal of Nuclear Medicine. 63 (12): 1919–1924. doi:10.2967/jnumed.122.263838.

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