Draft:Ron Kopito
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Comment: Gheus, it has to be a mistake in NYT because three different offline articles from 2001 mention that he is a professor. These articles are from Detroit Free Press, Arizona Daily Star and Sun Herald.HRShami (talk)
- Comment: Per NYT's 2002 article, he was an associate professor. Can you please fact-check your drafts? Gheus (talk) 10:38, 6 May 2025 (UTC)
- Comment: In accordance with the Wikimedia Foundation's Terms of Use, I disclose that I have been paid by my employer for my contributions to this article. HRShami (talk) 08:47, 6 May 2025 (UTC)
Ron Rieger Kopito | |
|---|---|
| Born | 1954 |
| Nationality | American |
| Occupation(s) | Cell biologist and academic |
| Academic background | |
| Alma mater | Bowdoin College (AB) Massachusetts Institute of Technology (PhD) |
| Academic work | |
| Discipline | Cell biology |
| Institutions | Stanford University |
Ron Rieger Kopito (born 1954) is an American cell biologist and academic holding the position of Professor in the Department of Biology at Stanford University.[1] He is most known for his work on proteostasis, particularly the role of ubiquitin and UFMylation in protein and ribosome quality control in the mammalian secretory pathway.
Kopito is a Lifetime Fellow of the American Society for Cell Biology.[2]
Education
[edit]Kopito earned an A.B. in biochemistry from Bowdoin College in 1976. He then received his Ph.D. in nutritional biochemistry and metabolism from the Massachusetts Institute of Technology (MIT) in 1982.[3]
Career
[edit]Kopito was an NIH postdoctoral fellow and Lucille P. Markey Scholar at MIT and the Whitehead Institute from 1982 to 1986 under the mentorship of Harvey F. Lodish.[4] In 1987, he joined the faculty of the Department of Biological Sciences (now the Department of Biology) at Stanford University, and became a full professor in 1996.[5]
His research work has included genetics, cell physiological characterization of SLC4A anion transporters and the cystic fibrosis transmembrane conductance regulator, CFTR, defining the role of the ubiquitin proteasome system (UPS) in endoplasmic reticulum (ER) associated degradation (ERAD).[6] He coined the term aggresome[7] to describe intracellular inclusions that collect aggregated proteins and demonstrated that protein aggregates derived from the Huntington's disease gene product impair cellular proteostasis and can propagate between cells in a prion-like manner.[8] He discovered that UFMylation of the large ribosomal subunit is required for ribosome-associated quality control and translocon recycling at the ER,[9] resolving a 50-year-old cell biological mystery.[10]
Awards and honors
[edit]- 1985 – Lucille P. Markey Scholar Award, Massachusetts Institute of Technology[11]
- 1989 – Presidential Young Investigator Award, National Science Foundation[12]
- 1993 – Established Investigator Award, American Heart Association
- 2018 – Lifetime Fellow, American Society for Cell Biology[2]
Bibliography
[edit]- Kopito, Ron; Lodish, Harvey (1985). "Primary structure and transmembrane orientation of the murine anion exchange protein". Nature. 316: 234–238. doi:10.1038/316234a0.
- Kopito, Ron R.; Lee, Beth S.; Simmons, Donna M.; Lindsey, Ann E.; Morgans, Catherine W.; Schneider, Karin (1989). "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger". Cell. 59 (5): 927–937. doi:10.1016/0092-8674(89)90615-6.
- Gunderson, Kevin L.; Kopito, Ron R. (1995). "Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis". Cell. 82: 231–239. doi:10.1016/0092-8674(95)90310-0.
- Ward, Cristina L.; Omura, Satoshi; Kopito, Ron R. (1995). "Degradation of CFTR by the ubiquitin-proteasome pathway". Cell. 83 (1): 121–127. doi:10.1016/0092-8674(95)90240-6.
- Bennett, Eric J.; Shaler, Thomas A.; Woodman, Ben; Ryu, Kwon-Yul; Zaitseva, Tatiana S.; Becker, Christopher H.; Bates, Gillian P.; Schulman, Howard; Kopito, Ron R. (2007). "Global changes to the ubiquitin system in Huntington's disease". Nature. 448: 704–708. doi:10.1038/nature06022.
- Pearce, Margaret M. P.; Spartz, Ellen J.; Hong, Weizhe; Luo, Liqun; Kopito, Ron R. (2015). "Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain". Nature Communications. 6: 6768. doi:10.1038/ncomms7768.
- Scavone, Francesco; Gumbin, Samantha C.; Da Rosa, Paul A.; Kopito, Ron R. (2023). "RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 120 (16): e2220340120. doi:10.1073/pnas.2220340120.
References
[edit]- ^ "Stanford Profiles–Ron Kopito". Stanford University. Retrieved May 5, 2025.
- ^ a b "American Society for Cell Biology–Ron Kopito". American Society for Cell Biology. Retrieved May 5, 2025.
- ^ "Stanford University Department of Biology–Ron Kopito". Stanford University. Retrieved May 5, 2025.
- ^ Voboril, Mary (February 28, 1985). "Markey fellows get research awards". The Miami Herald. p. 629.
- ^ "Ron Reiger Kopito CV". Stanford University. Retrieved May 5, 2025.
- ^ "Research - The Kopito Laboratory". Kopito Lab.
- ^ Behl, Christian (1 August 2016). "Breaking BAG: The Co-Chaperone BAG3 in Health and Disease". Trends in Pharmacological Sciences. 37 (8): 672–688. doi:10.1016/j.tips.2016.04.007. ISSN 0165-6147.
- ^ "Infectious Hereditary Illness? Insights on Huntington's Disease - Innovations Report". Innovations Report. 10 February 2009.
- ^ Munich, Ludwig Maximilian University of. "Researchers reveal how cells regenerate protein factories at the endoplasmic reticulum". Phys Org.
- ^ "Enzyme discovery helps unravel decades-old ribosome mystery". Stanford University. Retrieved May 5, 2025.
- ^ "16 Are Given Markey Research Scholarships". The New York Times. Retrieved May 5, 2025.
- ^ "NSF Presidential Young Investigator Award". National Science Foundation. Retrieved May 5, 2025.
External links
[edit]- Ron Kopito publications indexed by Google Scholar