From Wikipedia, the free encyclopedia
Cytosolic non-specific dipeptidase (EC 3.4.13.18 ) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene .[ 5] [ 6] [ 7] catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids . The human enzyme uses manganese ions as a cofactor.[ 8] N -lactoyl amino acids, such as N-lactoyl-phenylalanine , via the process of "reverse proteolysis".[ 9] Beta-hydroxybutyric acid .[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000133313 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024644 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase" . The Journal of Biological Chemistry . 278 (8): 6521– 6531. doi :10.1074/jbc.M209764200 PMID 12473676 . ^ "Entrez Gene: CNDP2 carnosine dipeptidase 2" .^ Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes . London: Academic Press. pp. 1520– 1522. ^ "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens" .^ Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. (May 11, 2015). "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids" . Proceedings of the National Academy of Sciences of the USA . 112 (21): 6601– 6606. Bibcode :2015PNAS..112.6601J . doi :10.1073/pnas.1424638112 PMC 4450436 PMID 25964343 . ^ Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, et al. (2024). "A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites" . Cell . 188 (1): 175–186.e20. doi :10.1016/j.cell.2024.10.032 PMC 11724754. PMID 39536746 . {{cite journal }}: CS1 maint: multiple names: authors list (link )
Activity Regulation Classification Kinetics Types
