Chromophobe renal cell carcinoma
Chromophobe renal cell carcinoma (chRCC) is a rare type of kidney cancer, making up about 5–7% of all adult kidney tumors.[1] It develops from cells in the distal tubules of the kidney and has unique features under the microscope and at the genetic level, such as frequent loss of certain chromosomes and changes in genes like TP53 and PTEN.[2][3] Most chRCC cases are found at an early stage and tend to grow slowly, so patients usually have a good outlook.[1] However, a small number of cases can be more aggressive, especially if the tumor shows sarcomatoid features or necrosis.[1] Because chRCC is uncommon, there are few treatments designed specifically for it, so doctors often use the same therapies as for more common types of kidney cancer, even though chRCC may respond differently].[1][3]
References
[edit]- ^ a b c d Nerli R, Pattanshetti S, Ghagane S, Malur P (2015). "Chromophobe renal cell carcinoma: Comprehensive analysis of 11 cases". Clinical Cancer Investigation Journal. 4 (1): 9–12. doi:10.4103/2278-0513.149023.
- ^ Lobo J, Ohashi R, Amin MB, Berney DM, Compérat EM, Cree IA, Gill AJ, Hartmann A, Menon S, Netto GJ, Raspollini MR, Rubin MA, Tan PH, Tickoo SK, Tsuzuki T, Turajlic S, Zhou M, Srigley JR, Moch H (October 2022). "WHO 2022 landscape of papillary and chromophobe renal cell carcinoma". Histopathology. 81 (4): 426–438. doi:10.1111/his.14700. PMID 35596618.
- ^ a b Linehan WM, Walther MM, Zbar B (December 2003). "The genetic basis of cancer of the kidney". The Journal of Urology. 170 (6 Pt 1): 2163–72. doi:10.1097/01.ju.0000096060.92397.ed. PMID 14634372.
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