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Arthur S. Tischler

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Arthur S. Tischler (born 1946) is an American surgical pathologist and professor of pathology at Tufts University School of Medicine.[1] He is best known for his research on catecholamine-producing neuroendocrine tumors, particularly pheochromocytoma[2] and paraganglioma.[3]

Career

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Tischler completed his medical training and pathology residency at Beth Israel Deaconness Medical Center and Harvard Medical School in Boston (1971–1976), serving as Chief Resident in 1976. He then worked as a pathologist at Walter Reed Army Medical Center (1976–1978), before joining Tufts Medical Center.

At Tufts, he became a senior pathologist and professor of pathology and laboratory medicine.[4]

Research

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Tischler's early research helped establish that pheochromocytoma cells could undergo neuron-like differentiation in response to nerve growth factor (NGF).[5]

In 1976, he and Lloyd Greene[6] co-developed the widely used PC12 cell line.[7]

He later co-developed MPC cell lines from genetically modified mice to study neuroendocrine tumors.[8]

In 2020, he co-developed RS0, the first SDHB-mutant, SDH-deficient pheochromocytoma model.[9]

Leadership and editorial roles

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Tischler served as President of the Endocrine Pathology Society (2001–2002)[10] and was Editor-in-Chief of Endocrine Pathology (2002–2008).[11] He is also a founding member of the Pheochromocytoma Research Support Organization (PRESSOR), where he co-chaired the tumor models working group.

International classification work

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Tischler has contributed to the World Health Organization (WHO) classification of endocrine tumors, authoring chapters in the 2004,[12] 2017,[13] and 2024[14] editions. He also leads the expert panel on pheochromocytomas and paragangliomas for the International Collaboration on Cancer Reporting (ICCR).[15]

Recognition

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  • 2000 – Founding member of PRESSOR
  • 2011 – Science Honoree, PheoPara Alliance[16]
  • 2025 – Lifetime Achievement Award, Endocrine Pathology Society[17]

Research collaborations

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Tischler contributed to the Cancer Genome Atlas (TCGA) pheochromocytoma/ paraganglioma study,[18] and is a collaborator in the Australian-Asian-American Adrenal Alliance (A5)[19].[20]

Selected publications

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  • Tischler AS, Greene LA. "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells." Nature. 1975.[21]
  • Greene LA, Tischler AS. "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells..." PNAS. 1976.[22]
  • Powers JF, et al. "A xenograft and cell line model of SDH-deficient pheochromocytoma..." Endocrine-Related Cancer. 2020.[23]

References

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  1. ^ "Arthur Tischler, MD | Tufts Medicine". www.tuftsmedicine.org. Retrieved 2025-05-08.
  2. ^ Greene, L. A.; Tischler, A. S. (July 1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences of the United States of America. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi:10.1073/pnas.73.7.2424. ISSN 0027-8424. PMC 430592. PMID 1065897.
  3. ^ "Tufts Medical Center – Lead Investigator Dr. Arthur Tischler - SDHB Coalition". sdhbcoalition.org. 2020-03-24. Retrieved 2025-05-08.
  4. ^ "Arthur Tischler, MD | Tufts Medicine". www.tuftsmedicine.org. Retrieved 2025-05-08.
  5. ^ Tischler, AS; Greene, LA (1975). "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells". Nature. 258 (5533): 341–342. Bibcode:1975Natur.258..341T. doi:10.1038/258341a0. PMID 1105720.
  6. ^ "Lloyd A. Greene, PhD". Pathology. 2017-06-21. Retrieved 2025-05-08.
  7. ^ Greene, LA; Tischler, AS (1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi:10.1073/pnas.73.7.2424. PMC 430592. PMID 1065897.
  8. ^ Powers, JF; Evinger, MJ; Tsokas, P; Bedri, S; Alroy, J; Shahsavari, M; Tischler, AS (2000). "Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice". Cell and Tissue Research. 302 (3): 309–320. doi:10.1007/s004410000289. PMID 11131180.
  9. ^ Powers, JF; Cochran, B; Baleja, JD; Sikes, HD; Pattison, AD; Zhang, X; Lomakin, I; Shepard-Barry, A; Pacak, K; Moon, SJ; Langford, TF; Stein, KT; Tothill, RW; Ouyang, Y; Tischler, AS (2020). "A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats". Endocrine-Related Cancer. 27 (1): 337–354. doi:10.1186/s12964-020-00556-3. PMC 7171864. PMID 32312253.
  10. ^ "Endocrine Pathology Society". Retrieved 2025-05-07.
  11. ^ "Endocrine Pathology Journal – Endocrine Pathology Society". Retrieved 2025-05-07.
  12. ^ DeLellis, Ronald A., ed. (2004). Pathology and genetics of tumours of endocrine organs. World Health Organization classification of tumours. Lyon: IARC Press. ISBN 978-92-832-2416-7.
  13. ^ RV, Lloyd; RY, Osamura; G, Klöppel; J, Rosai (2017). WHO Classification of Tumours of Endocrine Organs. International Agency for Research on Cancer. ISBN 978-92-832-4493-6.
  14. ^ WHO classification of tumours: endocrine and neuroendocrine tumours (5th ed.). Lyon: International Agency for Research on Cancer, WHO. 2025. ISBN 978-92-832-4524-7.
  15. ^ Thompson, Lester D. R.; Gill, Anthony J.; Asa, Sylvia L.; Clifton-Bligh, Roderick J.; de Krijger, Ronald R.; Kimura, Noriko; Komminoth, Paul; Lack, Ernest E.; Lenders, Jacques W. M.; Lloyd, Ricardo V.; Papathomas, Thomas G.; Sadow, Peter M.; Tischler, Arthur S. (April 2021). "Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting". Human Pathology. 110: 83–97. doi:10.1016/j.humpath.2020.04.012. ISSN 1532-8392. PMC 7655677. PMID 32407815.
  16. ^ "Science Honorees". PheoPara Alliance. Retrieved 2025-04-23.
  17. ^ "Tufts School of Medicine on X: "Congratulations to Professor Arthur S. Tischler!"". X. March 28, 2025.
  18. ^ Fishbein, L (2017). "Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma". Cancer Cell. 31 (2): 181–193. doi:10.1016/j.ccell.2017.01.001. PMC 5643159. PMID 28162975.
  19. ^ https://x.com/a5_adrenal
  20. ^ Flynn, A (2025). "Multi-regional genomics of SDHB-mutated pheochromocytoma and paraganglioma". In Press.
  21. ^ Tischler, Arthur S.; Greene, Lloyd A. (November 1975). "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells". Nature. 258 (5533): 341–342. Bibcode:1975Natur.258..341T. doi:10.1038/258341a0. ISSN 1476-4687. PMID 1196362.
  22. ^ Greene, L A; Tischler, A S (July 1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi:10.1073/pnas.73.7.2424. PMC 430592. PMID 1065897.
  23. ^ Powers, James F.; Cochran, Brent; Baleja, James D.; Sikes, Hadley D.; Pattison, Andrew D.; Zhang, Xue; Lomakin, Inna; Shepard-Barry, Annette; Pacak, Karel; Moon, Sun Jin; Langford, Troy F.; Stein, Kassi Taylor; Tothill, Richard W.; Ouyang, Yingbin; Tischler, Arthur S. (June 2020). "A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats". Endocrine-Related Cancer. 27 (6): 337–354. doi:10.1530/ERC-19-0474. ISSN 1479-6821. PMC 7219221. PMID 32252027.
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