ACEA-1328
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| Names | |
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| IUPAC name
6,7-dimethyl-5-nitro-1,4-dihydroquinoxaline-2,3-dione
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C10H9N3O4 | |
| Molar mass | 235.199 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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ACEA-1328 is an NMDA receptor antagonist.
Pharmacodynamics
[edit]ACEA-1328 acts as an antagonist of the glycine site at the NMDA receptor.[1]
Effects
[edit]Opioid tolerance
[edit]A study on mice has shown that ACEA-1328 was able to increase the analgesic action of morphine. It was also shown that it can reduce the formation of tolerance to morphine.[2]
Cocaine overdose
[edit]ACEA-1328 (along with other drugs) has been shown to be able to reduce convulsions induced by a cocaine overdose.[3][4]
References
[edit]- ^ Lutfy, K.; Doan, P.; Nguyen, M.; Weber, E. (1999-11-12). "Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance". European Journal of Pharmacology. 384 (1): 1–5. doi:10.1016/s0014-2999(99)00622-6. ISSN 0014-2999. PMID 10611412.
- ^ Lutfy, K.; Doan, P.; Weber, E. (November 1999). "ACEA-1328, a NMDA receptor/glycine site antagonist, acutely potentiates antinociception and chronically attenuates tolerance induced by morphine". Pharmacological Research. 40 (5): 435–442. doi:10.1006/phrs.1999.0538. ISSN 1043-6618. PMID 10527659.
- ^ Matsumoto, R. R.; Brackett, R. L.; Kanthasamy, A. G. (1997-11-12). "Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity". European Journal of Pharmacology. 338 (3): 233–242. doi:10.1016/s0014-2999(97)81926-7. ISSN 0014-2999. PMID 9424017.
- ^ Brackett, R. L.; Pouw, B.; Blyden, J. F.; Nour, M.; Matsumoto, R. R. (2000-01-28). "Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex". Neuropharmacology. 39 (3): 407–418. doi:10.1016/s0028-3908(99)00151-3. ISSN 0028-3908. PMID 10698007.