3-Me-PCE

3-Me-PCE
Legal status
Legal status	DE: NpSG (Industrial and scientific use only);
Identifiers
	IUPAC name N-Ethyl-1-(3-methylphenyl)cyclohexanamine;
CAS Number	2201-64-1;
PubChem CID	154133693;
ChemSpider	74893746;
CompTox Dashboard (EPA)	DTXSID501343119;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES CCNC1(CCCCC1)c2cc(C)ccc2;
	InChI InChI=1S/C15H23N/c1-3-16-15(10-5-4-6-11-15)14-9-7-8-13(2)12-14/h7-9,12,16H,3-6,10-11H2,1-2H3; Key:USOQORZXGGZQGO-UHFFFAOYSA-N;

3-Me-PCE is the 3-methyl derivative of the internationally controlled substance Eticyclidine (PCE). It shares structural similarities with 3-MeO-PCE and 3-HO-PCE. 3-Me-PCE first appeared in the scientific literature in 2015 in the context of synthesis and analytical caracterization of a series of arylcyclohexylamines by Wallach et al. It is believed to produce ketamine-like dissociative effects predominantly via antagonism of NMDA receptors.^[1] Anecdotal evidence of its efficacy dates back to 2022 and assigns it a potency similar to other PCE analogs.^[2] The EUDA issued a notification of its first analytical identification in March 2024.^[3]

References

^ Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, et al. (2016). "Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines". Drug Testing and Analysis. 8 (8): 801–815. doi:10.1002/dta.1861. ISSN 1942-7611. PMID 26360516.
^ "3-Me-PCE - Erowid Exp - 'The Electric Fog'". www.erowid.org. Archived from the original on 2023-09-08. Retrieved 2025-06-08.
^ "EU Early Warning System Formal Notification: N‑ethyl‑1‑(3‑methylphenyl)cyclohexan‑1‑amine (3‑Me‑PCE)" (PDF). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). 11 March 2024. Retrieved 9 June 2025.

[1] Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, et al. (2016). "Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines". Drug Testing and Analysis. 8 (8): 801–815. doi:10.1002/dta.1861. ISSN 1942-7611. PMID 26360516.

[2] "3-Me-PCE - Erowid Exp - 'The Electric Fog'". www.erowid.org. Archived from the original on 2023-09-08. Retrieved 2025-06-08.

[3] "EU Early Warning System Formal Notification: N‑ethyl‑1‑(3‑methylphenyl)cyclohexan‑1‑amine (3‑Me‑PCE)" (PDF). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). 11 March 2024. Retrieved 9 June 2025.

[1]

[2]

[3]

See also

References