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Protein-coding gene in the species Homo sapiens
Repulsive guidance molecule A (RGMa ) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B , as well as ACVR2A and BMPR2 , it binds BMPs thereby activating the intracellular SMAD 1/5/8 signalling pathway.[ 5] protein is encoded by the RGMA gene .[ 6]
RGMa is a repulsive guidance molecule for retinal axons.[ 7] neogenin functions as a receptor for RGM.[ 8] neural tube induces apoptosis . The apoptotic activity of neogenin in the neural tube is associated with cleavage of its cytoplasmic domain by caspases .[ 9]
RGMA belongs to a family of repulsive guidance molecules that are (glycosylphosphatidylinositol)-linked cell-membrane-associated proteins. The three proteins, RGMa (this protein), RGMb and RGMc are 40-50% identical to each other, and share similarities in predicted protein domains and overall structure. All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins ).[ 10]
RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. RGMs can coordinate Smad -dependent and Smad-independent signalling of BMPs in prostate cancer and breast cancer cells.[ 11] [ 12] [ 13] [ 14] [ 15]
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